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Targeting zonulin attenuates arthritis Next, and most importantly, we directly blocked zonulin by larazotide acetate (AT-1001), a first-in-class TJ regulator, currently used in phase III clinical trials for celiac disease 29

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Among other factors, intestinal permeability is regulated by zonula occludens toxin (Zot, or zonulin)-mediated disengagement of the protein ZO-1 from the TJ protein complex 16

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