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Currently, AD4/NACA is undergoing clinical trial in Phase I/II (NCT04355689) for RP associated with Usher syndrome to assess the effect of this molecule on oxidative stress and its efficacy on these diseases

A similar effect was obtained also using rosmarinic acid, which showed anti-inflammatory and antioxidant role in rats subjected to ischemia and reperfusion procedure [234]
10.1002/mnfr.201000264

Additionally, thyroid hormones and cortisol influence the Kreb cycle [88, 87]

Nature 496 , 101105 (2013)
