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The need of the hour is to have more randomized, double-blind, placebo-controlled trials with a larger sample size, long term follow-up period, with well defined primary and secondary outcomes, targeted to evaluate the efficacy and safety of the skin-lightening effects of topical, oral and parenteral glutathione

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However, these cell types are far fewer in number in the liver than hepatocytes, which represent 7080 % of liver and are responsible for first-pass metabolism