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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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[PMC free article] [PubMed] [Google Scholar] 68.Estourgie-van Burk GF, van der Kuy PHM, de Meij TG, Benninga MA, Kneepkens CMF

The compounds are synthesized and co-lyophilized under stringent analytical grade standards to ensure absolute sequence integrity and an ultra-high purity profile, preventing immunogenic cross-contamination during complex research protocols