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Menstrual irregularity, PCOS, premature ovarian insufficiency, difficulty conceiving and infertility, and pregnancy loss have been linked to sleep disturbances and disorders

doi: 10.1038/ng.3421

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These long-term thiomethyl metabolites have great potential in future clinical studies in order to provide a more reliable history of APAP ingestion in case of acute intoxication or to study underlying causes involved in APAP-induced hepatotoxicity