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doi: 10.3389/fimmu.2016.00035 2 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

Metformin, an AMPK activator, inhibits TGF-1-induced myofibroblast differentiation by promoting AMPK expression, leading to myofibroblast deactivation and apoptosis, reduction in the expression of type I collagen, fibronectin (FN), and -SMA in fibroblasts, and downregulation of ECM protein levels, thereby slowing or reversing PF (Rangarajan et al., 2018)

Curr Tradit Med 6(4):380387
Brain uptake of S-(12-dichlorovinyl)glutathione and S -(12-dichlorovinyl)- L -cysteine, the glutathione and cysteine S -conjugates of the neurotoxin dichloroacetylene
Cryptococcus neoformans infection in the central nervous system: the battle between host and pathogen

Consistent with positive data obtained from animal and other pre-clinical studies, several of these phase I/II studies reported trends towards increased disease control and objective response rates, although all were underpowered for detection of efficacy