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Integrating such metabolic modulators with ICIs, chemotherapy, or radiation may also prevent the emergence of resistant cancer stem-like cells clones by depriving them of metabolic plasticity

doi: 10.4236/jbise.2018.112003

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Name of the approval committee: The Ethics Committee of the First Affiliated Hospital of Jinan University

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

Cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine