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In addition, this pathway also promotes survival through AKT activation, suppression of mTORC1 and induction of autophagy (5356), the latter includes mitophagy (57), which plays a key role in limiting excess ROS production by removing damaged mitochondria (58)

Liver fibrosis

VIP, a 28-amino acid peptide, exhibits a diverse range of biological activities due to its interactions with multiple G protein-coupled receptors (GPCRs) from the VIP/PACAP receptor family (Harmar et al., 2012)

592,593 Moreover, due to the decrease of 3-hydroxykynurenine (a cytotoxic metabolite of KMO), the mice that lack active kynurenine 3-monooxygenase (KMO) will not develop into AKI after I/R injury

Smith MJ, Paton MCB, Fahey MC, Jenkin G, Miller SL, Finch-Edmondson M, et al

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