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[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Talib W.H., Alsayed A.R., Barakat M., Abu-Taha M.I., Mahmod A.I

Glutathione is believed to inhibit melanin production, leading to a brighter complexion

However, for confirmed B12 deficiencyparticularly pernicious anaemia or neurological symptomsintramuscular hydroxocobalamin injections remain the first-line treatment in the UK, as recommended by NICE and the British Society for Haematology

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The transcription factor p53 also plays a dual role in melanocyte defense by upregulating tyrosinase, a key enzyme in melanogenesis, and enhancing the antioxidant response via the Nrf2 pathway 17 , but also it can stop the melanocyte cell cycle, even leading to apoptosis 79

Rotate sites to avoid localized tissue changes