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observed TP53 mutations in 10/55 (18%) patients with low and intermediate-1 risk MDS carrying del(5q), which render them at higher risk for disease evolution to AML [527] Another investigation reported TP53 mutations in 17% of lower-risk MDS with isolated del(5q),associated with shorter survival [554]

doi: 10.1038/s41380-020-00920-2, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Stevens J

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doi: 10.1097/PHM.0b013e3181f1c00e