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Receptor-mediated transcytosis Receptor-mediated transcytosis (RMT) begins when the ligand attaches to particular receptors on the luminal side of vascular endothelial cells, triggering membrane invagination followed by endocytosis

This has been observed in clinical practice where 34% of patients co-prescribed metformin alongside PPIs were vitamin B 12 deficient, significantly greater than those on metformin (22%) or PPIs (26%) monotherapy, suggesting an additive effect

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