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In normal physiologic state, the brain parenchyma is only subject to nascent immune surveillance, however during inflammation, the elevated pro-inflammatory markers induce the increased expression of adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells of the BBB (Varatharaj and Galea, 2017

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This triggers protein kinase A (PKA), initiating intracellular signaling

(B) Testicular section of CE group rat shows normal spermatogenesis and cell arrangement in the seminiferous tubules

When ADHD is the first label, shutdowns during transitions, rigid routines, or intense distress about schedule changes may be misread as ADHD behavioral issues rather than as Autistic responses to uncertainty, unexpected change, and the deep discomfort of routine disruption