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They are classified into major groups based on their mechanism of action: 1

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This hypothesis was supported by the Gorelik study which found no benefit in non-obese patients 92 whilst a smaller study by Anderson et al

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Conversely, BAT is characterized by its ability to burn energy and produce heat, whereas it enriches mitochondria content and the action of uncoupling protein 1 (UCP-1), which helps in heat generation from fats