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Genotoxicity assessment, including genetic toxicology testing, is an essential component of safety assessment for all types of chemicals, such as pharmaceuticals, pesticides, food substances, bulk chemicals, and cosmetics

Myosin light chain phosphatase is a downstream target of Rho-kinase in endothelin-1-induced transactivation of the TGF- receptor

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Mechanistically, NK cell function is promoted via MyD88-dependent IL-12 and IL-18 production by DCs and macrophages, mediated through the NF-B and MAPK pathways, which leads to increased pro-inflammatory cytokine expression [116]

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