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Genua I, Cusi K

[DOI] [PMC free article] [PubMed] [Google Scholar] Howden R., Anderson C.R., Goldsbrough P.B., Cobbett C.S

doi:10.1016/j.numecd.2022.05.008 Jerneren F, Cederholm T, Refsum H, et al

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In HFD-induced NAFLD rats, the hepatoprotective effect of Jiaogulan (Gynostemma pentaphyllum (Thunb.) Makino) has been correlated with specific modulations of the gut microbiota (e.g., a reduced Firmicutes/Bacteroidetes ratio, increased Lactococcus, decreased Ruminococcus) and the preservation of intestinal barrier integrity, pointing to microbiota-mediated pathways as a likely component of its action [133]

FDA submission is anticipated late 2026 / early 2027 per Eli Lilly investor communications
