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Average body weight reduction: 5 mg weekly: 16.0% reduction (approximately 35 pounds for a 220-pound person) 10 mg weekly: 21.4% reduction (approximately 47 pounds) 15 mg weekly: 22.5% reduction (approximately 50 pounds) Placebo: 2.4% reduction Percentage of participants achieving clinically significant weight loss: 5% or more weight loss: 85% at 5 mg, 89% at 10 mg, 91% at 15 mg 10% or more weight loss: 69% at 5 mg, 78% at 10 mg, 84% at 15 mg 20% or more weight loss: 32% at 5 mg, 49% at 10 mg, 57% at 15 mg Look at those numbers carefully

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Social media influencers followed, and eventually, as is the case in trend cycles, so too did the average person who could afford the monthly price tag for GLP-1s

Brains were collected, and the LH was dissected immediately after the last feeding session

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The distribution of potential effect modifiers (HbA 1c and body weight at baseline) was deemed sufficiently similar across all treatment comparisons to assume that a network meta-analysis was appropriate (ESM Figs 2 and 3)