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Industrialization, rural areas, well water, plant-derived toxins, bacterial and viral infection, and exposure to organic solvents, carbon monoxide and carbon disulfide are some of the broad environmental factors on the prevalence of PD (Tellier et al., 2022)

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Some people may develop hypothyroidism from an iodine deficiency

95% confidence intervals 1.424.02

Also, with the current high level of concern about possible skin damage from sun exposure, many people cover up or use so much sunscreen that the sun cannot access their skin to make vitamin D3

Meng XM, Nikolic-Paterson DJ, Lan HY