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may cause skin and eye irritation, respiratory irritation, or drowsiness/dizziness

Due to its delocalized positive charge, berberine can disrupt mitochondrial membrane potential and upregulate the content of ROS

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This cytokine shift, which enhances antiviral and antitumor immune responses, which are critical for the elderly to fight age-associated diseases, is linked to an increase in NK cell numbers, potentially explaining the enhanced IFN- production [212]

However, FOXO1 inhibition reduced the viability of all tested cell lines, particularly cells with lower nuclear FOXO1, including KRAS wild-type cells (Appendix Fig

12 (11), 12721277 (2013) Mustikaningtyas, D., Widyarti, S., RifaI, M., Widodo, N.: Proposed Mechanism of Antibacterial Activity of Glutathione by Inhibition of the d-Alanyl-d-alanine Carboxypeptidase Enzyme