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In terms of the bioactive molecules involved in angiogenesis, we found that Compound C dramatically abolished the Nar-evoked expression elevation of PCNA, HIF-1, MMP-1, and MMP-9, which acted as positive regulators of angiogenesis

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Thus, it is reasonable to maintain folic acid supplementation throughout pregnancy, even after closure of the neural tube, in order to decrease the risk of other potential problems during pregnancy
