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Although candidate biomarkers such as neurofilament light chain, growth hormonereleasing hormone, aminoacylase 1, syn, and glucosylsphingosine have been proposed, none reliably capture shortterm therapeutic effects due to variability and weak clinical correlation [292, 293, 294, 295]

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Each experimental condition was carried out in six replicates ( n = 6), and the mean of three technical replicates was used for data analysis

Add reconstitution solvent slowly and directly onto the lyophilised powder, not against the vial wall

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