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Immunologically, a key feature is abnormal immune activation: overactivated T cells generate various cytokines, including interleukin-23 (IL-23) and tumor necrosis factor- (TNF-) 4 , which cause excessive proliferation and abnormal differentiation of keratinocytes, leading to the formation of classic psoriatic skin lesions 5

The privacy we give up: Personal information that we make public on our profiles, including our date of birth, education, even employment history

KO, n = 7 representative from 2 independent experiments, p = 0.7441) (b) , tGSH levels (p = 0.001, WT, n = 4

2017;37:e10814

The high-affinity NMDA-Rs on the beta cell are already saturated at physiological glutamate concentrations in the islet, and are mainly activated through depolarization of beta cells [121]

Oxidative stress is of great importance in the pathogenesis of HE, while the underlying mechanism remains to be clarified