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Suzuki, H., Kumagai, H., and Tochikura, T

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Moreover, despite recent findings of a guanine nucleotide exchange factor (GEF) and GAPs for the Rag GTPases and the requirement of vacuolar H + -ATPase (v-ATPase, a proton pump for lysosomal acidification) in mTORC1 activation (4145), the signaling mechanism from amino acids to a Rag GEF and/or GAP is still unknown

Immunohistochemistry images were quantified by staining intensity using ImageJ

Similarly, inhibition of CD38 in aged mice boosted NAD + levels, improving exercise capacity, but in this case, no significant changes in mitochondrial biogenesis-related genes were observed 138