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Heat, light, and even excessive agitation are the enemies of this delicate structure

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Elevated Dietary -6 Polyunsaturated Fatty Acids Induce Reversible Peripheral Nerve Dysfunction That Exacerbates Comorbid Pain Conditions

These effects can further reduce neuron damage and apoptosis

This makes BDNF ideally suited to shape developing and fine tune mature synaptic circuits through activity-dependent local synthesis and secretion (compare chapter Physiological context of regulated release of BDNF section in this review, see also Johnestone and Mobley 2020)