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Glucose and Glycogen Pathways In studies assessing glycogen metabolism, Fragment 176-191 was observed to slightly elevate blood glucose and lactate levels in murine models
[DOI] [PubMed] [Google Scholar] 46.Houtkooper R
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Due to the compounds plasma half-life of approximately 3.86.9 hours [4] , twice-daily (BID) dosing may provide more sustained NNMT inhibition
NNMT activity increases with age, obesity, and metabolic dysfunction
