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Description
& Maloney, A
Implementing prognostic and predictive biomarkers in CRC clinical trials

Drug safety testing involved analyzing serum biochemical markers (CK, CKMB, ALT, AST, CREA, BUN) to evaluate potential adverse effects on myocardial, liver, and renal function in treated mice [2]
Preclinical and observational data available for the individual components

That motivated me a little more, gave me the drive

Elevated homocysteine would suggest impaired methylation flux
