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Promising nonclinical evidence suggests that equipotent MC3R agonism can improve the therapeutic window between weight loss and cardiac activation, suggesting 710GOs potential as a monotherapy beyond its demonstrated success in combination with semaglutide ( Key limitations of GLP-1 therapies have driven the swift development of differentiated assets for the treatment of obesity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Almeida D., Colombini A., Machado M

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Popolazioni speciali Pazienti con insufficienza renale Pazienti con grave compromissione della funzionalit renale non devono essere trattati con la somministrazione cronica per via orale di alte dosi di levocarnitina perch pu indurre un accumulo dei metaboliti potenzialmente tossici trimetilamina (TMA) e trimetilamina?N?ossido (TMAO), vedere paragrafo 4.4

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