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This limitation highlights the need to pair such therapies with agents that promote epithelial repair and balanced mucin production such as cystic fibrosis transmembrane regulator modulators, growth factors or emerging mucosal regenerators to fully restore airway defence and function 251,252

Assessment of skin issues, personalised treatment plans, monitoring and follow-up, resolving safety concerns, integration with other therapies, education and guidance, and monitoring for side effects are all important reasons to seek expert advice

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The activation of the Na + /H + exchanger (NHE), as an attempt to correct acidosis, leads to an accumulation of intracellular Na + , which in turn inhibits Ca 2+ extrusion through the Na + /Ca 2+ exchanger (NCX), thereby contributing to calcium overload [163]