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Various causes have been previously proposed, including nutritional factors, infections and toxins, hygiene hypothesis, lifestyle hypothesis, and endogenous factors [137]

Using UQ1, a derivative of the mitochondrial electron transport chain cofactor CoQ10, as the electron acceptor, we observed that both AIF and NDI1 exhibited comparable but significantly enhanced NADH oxidase activity compared to when O 2 was the electron acceptor, whereas AIF3 significantly reduced NADH oxidase activity (Fig

Ligament and tendon repair through regeneration using mesenchymal stem cells

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doi: 10.1016/j.freeradbiomed.2012.02.030

Metabolic bioactivation as a pathogenic mechanism