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Relative quantifications were normalized to the reference genes tba-1 and F35G12.2

However, reported benefits are not uniform across all trials or populations, and effect sizes are often modest, highly strain-specific, and influenced by background diet and host factors, which complicates broad generalization of these findings (13)

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Furthermore, another study investigated polyphenol-rich acetone/water extracts from Hamamelis virginiana in vitro

Although epacadostat achieved a favorable response rate of 55% in combination with pembrolizumab for the use in patients with solid tumors from a phase I/II trial, which led to a phase III study to evaluate the efficacy of epacadostat in 706 unresectable melanoma patients, the results from the larger trial revealed that epacadostat plus pembrolizumab did not provide an improved overall survival or progression-free survival