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It is not yet a first-line recommendation
It has been demonstrated that GGT is overexpressed in many human malignancies including primary GBMs, whereas GGT expression is low in normal brain astrocytes and neurons 4,15,16,17,18,19
nonetheless, their best application will rely on baseline micronutrient assessment, cautious patient selection, and consistent dosage schedules
Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
10.1186/s12974-016-0516-8 8 BianM.DuX.WangP.CuiJ.XuJ.GuJ.et al (2017)
The first reaction is the formation of the dipeptide -glutamylcysteine (GGC) from the amino acids L-glutamic acid and L-cysteine
