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D., Fisher, P

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a , CODEX image of a bifurcated villi observed in P3 (n = 3 biological repeats with 2 technical repeats each)

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The appearance of REES is linked to the reorientation time of the polar solvent molecules (water) surrounding an excited polar fluorophore (tryptophan) with changed electronic state (and, thus, changed dipole moment) to reach a new, lower-energy equilibrium with the excited fluorophore

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While other atypical Parkinsons syndromes (APS), such as PSP, multisystemic atrophy (MSA), and corticobasal ganglion syndrome (CBS), are characterized by a marked increase in NfL level of CSF due to myelin axonal involvement, this pathological process is not typical in the early stages of PD (von Widekind et al., 2020)

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