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The active sites of the SjTrx1i (A) and SjTRP14 (B) are presented for both their oxidized and reduced states

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In the first shuttle, cytosolic NADH is oxidized to NAD + by MDH1 in conjunction with the reduction of oxaloacetate (OAA) to malate

Nature 586 , 509515 (2020)
Oxidative stress and respiratory system: Pharmacological and clinical reappraisal of N-acetylcysteine