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Study selection Studies were selected on the basis of the following inclusion criteria: All studies must be controlled clinical trials or randomized controlled trials (RCTs) Multiplesequence crossover studies must have an appropriate washout period of at least 2 weeks All study subjects must be diagnosed with MS The experimental group must be administered modafinil as an intervention Studies must assess relevant quantitative outcomes of fatigue Studies were excluded from the review on the basis of the following criteria: Review articles and observational studies Interventions using enantiomers or derivatives of modafinil (i.e., armodafinil) Singlearm studies and singlesequence crossover studies Studies where no relevant outcomes of fatigue are assessed Studies ineligible for pooling (featuring comparator groups that exhibit distinct characteristics not evaluated in any other included study) Irrelevant/Animal studies Studies where data could not be retrieved 2.4

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Because muscle L-Carnitine levels help determine the exercise capacity of muscles, supplementing hard-working animals can improve energy supply, increase the use of fat as fuel and reduce reliance on glycogen

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HS and LS groups were matched for gender, age and IQ but differed on all schizotypy measures, as intended by design

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