lipid hydroperoxides glutathione Scheme illustrating the generation and fate of in Role of iron, glutathione and

Furthermore, NRF2 enhances drug resistance by inducing the expression of ATP-binding cassette (ABC) transporters such as ABC sub-family C member 1 (ABCC1) and ABC sub-family G member 2 (ABCG2), which efflux chemotherapeutic agents out of cells

Glutathione is produced naturally in the liver

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

For GSH-pathway measurements, each colored symbol represents an individual patient (circles = HC, triangles = M/MA, squares = SA) or individual human cell line, which can be followed through multiple figures

Berhane et al., 1994

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