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30 To date over 200 individual nucleotide changes which cause pathogenic mutations have been described (Figure 4, RettBASE

Nucleus 5 , 402426 (2014)

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Some studies have suggested that statins may upregulate toll-like receptors on activated dendritic cells, enhance the secretion of proinflammatory cytokines, and could be related to the development of autoimmune hepatitis

Biol Psychiatry 61:7886

These studies and the NATHAN studies have pointed out the change in the natural history of DN with the advent of therapeutic lifestyle change, statins and ACE inhibitors, which have slowed the progression of DN and drastically altered the requirements for placebo-controlled studies