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In addition, the authors review the potential implications of new discoveries about the molecular targets of metformin for the development of antidiabetic and anticancer therapies.

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Under diabetic conditions, metabolic stressors, including chronic hyperglycemia and lipotoxicity, directly promote PANoptosome assembly by disrupting cellular energy balance, inducing mitochondrial dysfunction, and accumulating reactive oxygen species

Cartesian coordinates of the model compounds are given in the downloadable PDF file (see Supporting Information)

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