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& Morgan, B.A

These changes encompass the 2nd, 8th, 15th, and 27th amino acids, and such adjustments might arguably extend the peptide's lifespan against enzymatic breakdown, particularly by enzymes like dipeptidyl peptidase-4 (DPP-4)

Its role is especially crucial in the induction of ferroptosis, an iron-dependent cell death pathway, positioning it as a context-dependent modulator of cancer progression, neurotoxicity and neurodegeneration

Surgical treatment is foreseen for a selected group of patients (e.g., limited disease and eligible for platinum therapy) and a remaining matter of debate

doi: 10.1152/ajpcell.00946.2024 43 WangWLiLLiXChenJWangRYangQet al
