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We hypothesized that oxidation of GSH to glutathione disulfide (GSSG) in the epithelial lining fluid (ELF) of children with severe asthma would contribute to altered airway macrophage (AM) GSH homeostasis and AM cellular dysfunction

Mechanisms include providing substrate for tissue synthesis, stimulating fibroblast and chondrocyte activity, and potentially specific peptide signaling

Low bone mineral density is usually then confirmed on a subsequent DXA (79)

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However, the utilization of florescent probes requires expensive equipment

von ElmEAltmanDGEggerMPocockSJGtzschePCVandenbrouckeJPet alThe strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies