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We found that some giant nLDs in intestinal cell contact what appear to be lamin-deficient regions of the nuclear lamina, suggesting that these sites might be prone to rupture (panel 2, Fig 13F and S2 Fig)

But before they reach your small intestine, they have to survive your stomach acid and enzymes

doi: 10.1038/s41598-019-45419-1 68 PellegriniCFornaiMDAntongiovanniVAntonioliLBernardiniNDerkinderenP

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This process regulates mtROS accumulation via SH3GLB1, kynurenine metabolism via GOT2, and NDP52-induced mitochondrial autophagy

References Shermak MA