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Notably, intestinal Fusobacterium nucleatum infection has been shown to activate TLR4/AK T /Keap1/NRF2 signaling leading to increased 12(13)-EpOME production and oncogenesis

The light modifier subunit GCLM is enzymatically inactive but plays an important regulatory function by lowering the Km of GCLC for glutamate and raising the Ki for GSH [7, 8]

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Funding This study was supported by the Japan Society for the Promotion of Science (Grant numbers 20K07623, 22K06756, 23K06642 and 25K10100)

Liver histopathology The sections of hepatic tissues from control, LCS, and Cur-treated rats revealed normal central vein architecture characterized by intact endothelial lining, regular hepatic cords containing large hepatocytes with vesicular, central, and spherical nuclei, as well as normal blood sinusoids (Fig

COVID-19 can irritate the immune system by upregulating inflammation