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The consequence: too much NAM.13 To manage the excess, your cells increase levels of the enzyme nicotinamide N-methyltransferase (NNMT) to convert NAM to methylnicotinamide

The DNA-damage response in human biology and disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Chen J., Guccini I., Di Mitri D., Brina D., Revandkar A., Sarti M., Pasquini E., Alajati A., Pinton S., Losa M., et al

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Future research should prioritize the integration of single-cell and spatial multi-omics data to systematically map cell death interaction networks, and combine these insights with innovative delivery systems and patient stratification strategies