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This evolution is driven by selective pressure from antibiotic use, with factors such as decades of overuse, incorrect dosing, and the widespread use of antimicrobials in livestock, contributing to the selection of resistant strains

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Indeed, 17-AAG (Tanespimycin) and 17-DMAG (Alvespimycin), two synthetic derivates of Geldanamycin antibiotic, used as HSP90 inhibitors, improve physiological parameters in bleomycin-induced pulmonary fibrosis mice model 25,26

Overall, our data suggest that upfront incorporation of the mTOR inhibitor rapamycin in CAR T cell manufacturing may be a means to enhance anti-tumor efficacy in patients