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Assessment of metabolic signaling showed that iron overload was associated with (i) decreased Akt phosphorylation at both Thr308 (Akt-T308) and Ser473 (Akt-S473) and (ii) increased AMPK phosphorylation (Thr172) (Figure 6B)

This matters because according to research from the Cleveland Clinic, even mild dehydration forces your heart to work harder while making it more difficult for your body to regulate temperature

Prospective MRI Assessment of Serial Dose-Response Kinetics of Swallowing Muscles in Oropharyngeal Cancer Patients Treated With Radiation Therapy and Correlations With Dynamic Imaging Grade for Swallowing Toxicity (DIGEST)