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This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism

10.1001/jamaneurol.2013.5847 JAMA Neurol

Because its based on the fat-related fragment of GH, its used as a tool to study those metabolic processes specifically, rather than the full sweep of effects whole growth hormone produces

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