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This action relaxes smooth muscle in blood vessel walls, promoting vasodilation and increased blood flow to hair follicles

Thompson and Bizzarro, 2008)

For example, the general anesthetic drug, thiopental, which is a highly lipid-soluble agent, induces anesthesia within seconds owing to drug rapid equilibration between blood and brain

This in silico assessment showed that model-based approaches were superior to other strategies (label recommendations, TDM-guided stepwise dosing, TDM-guided proportional dosing)

Appelman-Dijkstra, N
