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Stress-induced Ca 2+ spikes serve as secondary messengers, activating calcium-dependent protein kinases (CDPKs) and calcineurin B-like proteins (CBLs) that regulate stress-responsive gene expression (Jain et al., 2018)

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The participants in this study did not report any serious adverse side effects

Results are dose dependent, and the higher glutathione concentrations delivered by IV therapy can accelerate outcomes compared to injections alone

Tokunaga R, Zhang W, Naseem M, Puccini A, Berger MD, Soni S, et al

Although d-penicillamine also shared advantage of oral administration when prescribed at 250 mg given four times for five days of therapy or 40 mg/kg/day for chronic therapy