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In men, the restrictions are due to the potential for reversible male infertility, testicular problems, and the risks of neurodevelopmental conditions in children born to men taking valproate in the 3 months before conception

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Thus, mTORC1 promotes the nuclear translocation of the cAMP response element-binding protein (CREB) which stimulates the transcription of the anti-apoptotic gene MCL-1 in the nucleus and the upregulation of the Bcl-2 family protein myeloid cell leukemia 1 (Mcl-1) [300]

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[DOI] [PubMed] [Google Scholar] 9.Sikka SC, Hellstrom WJ
