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For a 75kg (165lb) person, this suggests 2.25 to 3.75mg daily, aligning with the 10 to 20 unit range at 20mg/mL concentration

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Its relevance to neuropathy comes through serotonin synthesis promotion and neuroprotective gene expression modulation

In some embodiments, the otoprotectant is any one of the following compounds: In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (I): In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (II): wherein ring A is optionally attached and is a 5-7 membered ring that is aromatic or non-aromatic and can contain one more heteroatoms (N, O, or S atoms)