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After reaching duodenum, haptocorrin-vitamin B12 complex undergoes cleavage due to the changes in pH and breakdown of haptocorrin by the pancreatic proteases, which leads to the release of vitamin B12 in its free form

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Thus all of the DNA synthetic effects of B 12 deficiency, including the megaloblastic anemia of pernicious anemia, resolve if sufficient dietary folate is present

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In this case, the concentration of the released fatty acid molecules exceeds their corresponding solubility limits, fatty acid precipitation may occur, leading to the formation of sub-visible and/or visible particles (Kishore et al., 2011a