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In macrophages, glutamate activates the NF-B signaling pathway, which upregulates genes related to NOD-like receptor protein 3 (NLRP3) activation

[DOI] [PMC free article] [PubMed] [Google Scholar] 240.Dominguez J.F., Ng A.C., Poudel G., Stout J.C., Churchyard A., Chua P., Egan G.F., Georgiou-Karistianis N

This leads to a more even skin tone and enhances overall skin brightness

[DOI] [PubMed] [Google Scholar] Mohanraj VJ, Barnes TJ, Prestidge CA

[DOI] [PubMed] [Google Scholar] 60.Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH, Jr, Goin-Kochel RP, Vaz FM, Beaudet AL, et al